From southern New Jersey

Take the Holland Tunnel to Canal St. Travel on Canal St to Lafayette Ave. Turn left on Lafayette and travel north to E Houston St. Make a right onto E Houston and make a left onto Bowery. Travel north on Bowery to Second St, pass Second Ave to Cathedral which will be in the middle of the block on the right.

From northern New Jersey and the George Washington Bridge

Cross over GW Bridge. Look for signs for Harlem River Dr S. Harlem River Dr becomes West Side Highway south. Continue south and exit at 23 St. Take 23 St to Second Ave and continue south to Second St. Turn left, and the Cathedral is in the middle of the block on the right.

From Long Island

Take the Midtown Tunnel to Manhattan. Follow signs for Second Ave south and continue south to Second St. Turn left, and the Cathedral is in the middle of the block on the right.